Visualizing fibril growth of an artificial peptide containing two palmitoyl membrane anchors in a model raft mixture consisting of DOPC/DPPC/Chol 1:2:1. The peptide partitions only into the fluid (ld) and not into the raft (lo) domains. Growth of fibrils begins within the first 30 min after injection of the peptide solution into the AFM Tapping Mode fluid cell and fibrils are around 90-400 nm long and 1.0-4.9 nm thick. The image was taken with a MultiMode (Digital Instruments) and scan size is 4.3 µm.
Courtesy of Katrin Weise (1), Diana Olschewski (2), Christian Becker (2), Roland Winter (1)
(1) Physical Chemistry I Biophysical Chemistry, Department of Chemistry, University of Dortmund, Otto-Hahn-Str.6, 44227 Dortmund, Germany
(2) Max-Planck Institute of Molecular Physiology, Department of Physical Biochemistry, Otto-Hahn Str. 11, 44227 Dortmund, Germany
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